• Bile acids BAs are critical for facilitating the absorption

  2021-10-14

  

  Bile acids (BAs) are critical for facilitating the Z-Guggulsterone of dietary lipids and lipid-soluble vitamins in the intestines [6], [7]. At physiological levels, BAs function as signaling molecules and activate specific nuclear receptors [farnesoid X receptor (FXR), pregnane X receptor, and vitam

• Recently considerable effort has been invested

  2021-10-14

  

  Recently, considerable effort has been invested in developing FDPS inhibitors based on alternative scaffolds (including nonbisphosphonates) that allow other tissue types and parasite-derived forms of FDPS , to be targeted. There are several limits in analyzing inhibitors of FDPS activity: the most

• br What are the local exocytotic protein targets

  2021-10-14

  

  What are the local exocytotic protein targets of PKC? A direct method for PKC to potentiate insulin release would be to phosphorylate and activate components of the exocytotic machinery. Bulk measurements show that potentiation occurs by enhancement of the calcium sensitivity of exocytosis [56],

• The metal nanoparticles of gold Au silver

  2021-10-14

  

  The metal nanoparticles of gold (Au), silver (Ag), Platinum (Pt), Palladium (Pd) and/or their composites are also being widely used to develop electrochemical sensors because of their unique advantages such as (i) ease in immobilization of receptor molecules, (ii) catalysis of electrochemical reacti

• PNU-120596 To interrogate the molecular basis for the myocar

  2021-10-14

  

  To interrogate the molecular basis for the myocardial phenotype in mutant hearts, we performed quantitative real-time PCR (qRT-PCR) expression analysis of genes encoding critical endocardium-derived molecules including Nrg1 and Efnb2. Nrg1 expression was reduced in E13.5 mutant hearts as compared to

• The transcription factor Nrf is a master regulator of cytopr

  2021-10-14

  

  The transcription factor Nrf2 is a master regulator of cytoprotective responses to endogenous and exogenous stresses caused by reactive oxygen species (ROS) and electrophiles [6]. Nrf2 promoter polymorphisms are significantly associated with the development of gastric mucosal inflammation, either in

• br GSK The GSK family is highly conserved

  2021-10-14

  

  GSK-3 The GSK-3 family is highly conserved throughout evolution and is encoded by two genes, GSK-3α and GSK-3β, which are located in chromosomes 19q13.2 and 3q13.3 in human, respectively. Both GSK-3α and GSK-3β proteins exist in a variety of tissues with the highest levels found in chemokine rece

• br GPR is a class A

  2021-10-14

  

  GPR119 is a class A GPCR expressed on pancreatic β-cells and certain enteroendocrine channel modulator which upon activation with an agonist, increases insulin secretion in response to rising glucose levels. Mechanistically, this insulinotropic effect is bifurcated involving both GPR119-mediated

• We did however observe that niacin

  2021-10-14

  

  We did, however, observe that niacin treatment impaired DC accumulation in skin-draining lymph nodes (Fig. 2). Attenuated adaptive immunity, assessed using a contact hypersensitivity assay (Fig. 4), was observed, as would be expected from impaired DC accumulation in lymph nodes, though other mechan

• br The glycine transporter GlyT was originally identified as

  2021-10-14

  

  The glycine transporter 1 (GlyT1) was originally identified as a member of the solute carrier family 6 of sodium- and chloride-dependent neurotransmitter transporters . GlyT1 is expressed in the central nervous system and in peripheral tissues; mainly in erythroid cells, from erythroblasts in the

• Both anxiety like behavior and sucrose

  2021-10-14

  

  Both anxiety-like behavior and sucrose preference/intake were reduced in GPR40/FFAR1 KO male mice, while social behavior was normal in KO mice. These findings indicate that brain GPR40/FFAR1 is involved in the modulation of anxiety- and depression-like behavior in rodents. Previous studies have demo

• ICH induced striatal lesion produced a reduction of EAAT exp

  2021-10-14

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino AM 281 transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia (Rao

• GK also called hexokinase IV or D

  2021-10-14

  

  GK, also called hexokinase IV or D, is a glycolytic enzyme that converts (S)-(+)-Dimethindene maleate to glucose-6-phosphate. GK has unique characteristics compared with those of the ubiquitously expressed hexokinase isoforms I–III, and is predominantly expressed in the pancreas and liver. In pancre

• no one care We have expanded these studies by doing EEG reco

  2021-10-13

  

  We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA no one care or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA receptor antagonis

• Utilization of fascinating properties such

  2021-10-13

  

  Utilization of fascinating properties, such as localized surface plasmon resonance (LSPR), high fluorescent quantum yield, biocompatible nature, chromogenic and electrocatalytic functionality of several nanomaterials for histamine sensing is also quite evident where the nanomaterials have served as

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